Scientists have created a new way to use DNA to kill cancer cells, which could pave the way for a cure for the disease.
The method targets cells derived from cervical and breast cancer, as well as malignant melanoma cells in mice.
Scientists in @UTokyo_News_ru have designed artificial hairpinlike A DNA molecule capable of targeting and kill #crayfish cells by binding to microRNA (miRNA) molecules that are overproduced in some types of cancer. To study more: https://t.co/PbFH5mVu2Wrice.twitter.com/PAsDXqx6ed
— Inside Precision Medicine (@Inside_PM) December 25, 2022
He uses a cancer-killing DNA hairpin that is injected into cancer cells.
When injected into the body, it binds to molecules called miRNAs, which are produced in excess in some types of cancer.
Artificial DNA in shape like pins can be key rip open cancer, according to new research in university of Tokyo: https://t.co/D90Y5x5Mua#UTokyo#Research#Crayfish#Health#Care#The medicine#Biology#DNA#RNArice.twitter.com/CwreYLw4kZ
— UTokyo |東京大学 (@UTokyo_News_en) December 22, 2022
Once attached to the miRNA, it breaks down and forms longer strands of DNA, triggering an immune response.
The immune system has found it dangerous to overproduce microRNA cells, which activate the natural immune response that kills cancer cells.
The Japanese research team says their method is different from current ones and could usher in a new era of cutting-edge cancer drugs.
Unfortunately, cancer is a health problem and current treatments have their limitations, but DNA and RNA-based drugs are expected to help scientists eventually defeat it.
This is because DNA and RNA are vital information-transmitting molecules that can control the biological function of cells. It is expected to change the future of medicine and help treat other intractable diseases caused by viruses and genetic diseases.
The use of DNA and RNA to treat cancer has been difficult because it is difficult to get them to distinguish between healthy and cancerous cells. This means that the patient’s immune system can suffer if it attacks healthy cells.
However, this was the first time that scientists were able to develop a hairpin-shaped DNA strand that could activate a natural immune response to target and kill specific cancer cells.
“The results of this study are good news for clinicians, drug researchers, and cancer patients, as we believe they will give them new opportunities for drug development and drug policy,” said Professor Akimitsu Okamoto of the University of Tokyo, author of the book The Study.
He continued, “We will then aim to discover drugs based on the results of this study and study efficacy, toxicity, and potential routes of administration in detail.”
Detailed results are published in the Journal of the American Chemical Society.
Source: Independent
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from Technology - Asume Tech https://asumetech.com/developing-a-new-way-to-kill-cancer-cells-could-pave-the-way-for-a-new-generation-of-treatments/
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