concerns "disappearance" Men "nearly" .. Study warns of disappearance of male chromosome

The study led scientists to believe that the male Y chromosome may disappear in the future. This hypothesis arose after scientists investigated a species of Japanese spiny rat.

Scientists fear that men will disappear after they discover that endangered rats lack the male Y chromosome.

The mice in question no longer depended on the old male chromosome to encode male sex characteristics. Instead, a “completely new one” was developed to replace it, according to scientists at the University of Hokkaido in an article published last month in the journal Proceedings. of National Academy of Sciences.

Scientist Kuroiwa says that the Y chromosomes in many mammals, including us, decrease in size over tens of millions of years and may eventually disappear. Spiny Rat shows how this can happen, she says.

In the animal kingdom, there are many different sex determination systems, but in almost all mammals, sex depends on the X and Y chromosomes. If the fetus inherits two X chromosomes, it will become female. If he inherits X and Y, he becomes a man.

This is because the Y chromosome contains a gene called SRY, which turns on “male” genes on other chromosomes – the most important gene is SOX9, which stimulates testicular development.

The mouse from Amami-Oshima Island, one of the Amami Islands of the Satsunan Archipelago in Japan, is one of the few mammals that lacks two Y chromosomes. In addition, females, like males, have only one X chromosome.

It’s been a mystery for a long time. how The prickly rat Amami survives without a Y chromosome, but her secret was finally revealed. Is the human Y chromosome on in way out too much? https://t.co/jlBO827U3F

— New scientist (@newscientist) December 5, 2022

In fact, recent studies show that it is often lost from the cells as men age. But the loss of Y from the entire population leads to extinction, because there will be no more males.

To figure out how male spiny mice survive, Japanese researcher Asato Kuroiwa of Hokkaido University and her team first sequenced the genomes of several males and females, but found no variants unique to males.

Then they looked closely and found that in male mice, one of the two copies of chromosome 3 had a duplicated region next to SOX9.

Study warns about male chromosome

The study led scientists to believe that the male Y chromosome could disappear. in in future. This hypothesis appeared after scientists studied the Japanese prickly rat.

Details: https://t.co/bDzdNCKGlGrice.twitter.com/8HFcM37xTX

– RT (@RT_com) December 5, 2022

While mammalian Y chromosomes shrink and degrade in function over millions of years, analysis of mice on Amami Oshima Island shows that this new chromosome can now switch to male sex characteristics.

In a clearer sense, they found that SOX9 effectively replaces testicular determining factor or testicular determining factor (SRY) effectively. So, spiny mice have developed a way to force males to use a completely different chromosome. The team estimates that this method originated about two million years ago.

Researcher Kuroiwa and other scientists extrapolated the results of the experiment to humanity.

“There is no reason to believe that our Y chromosome is stronger than that of spiny mice,” Jenny Graves of Australia’s La Trobe University told New Scientist. Where I previously predicted that the Y chromosome would cease to exist within 10 million years.

She hypothesized: “When humans run out of a Y chromosome, they may die out (if we ourselves did not die out a long time ago) or they may develop a new sex gene that determines new sex chromosomes.”

Other researchers have noted that even if the disappearance of the Y chromosome meant the death of male mammals, it would not necessarily mean the end of the species.

“Females, by which I mean organisms that produce large gametes called eggs, can – in some species – self-fertilize,” Ruth Gorelik, a sexual evolution researcher at Carleton University, told Newsweek.

Source: RT

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